| First Author | Hosford DA | Year | 1992 |
| Journal | Science | Volume | 257 |
| Issue | 5068 | Pages | 398-401 |
| PubMed ID | 1321503 | Mgi Jnum | J:1484 |
| Mgi Id | MGI:50011 | Doi | 10.1126/science.1321503 |
| Citation | Hosford DA, et al. (1992) The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. Science 257(5068):398-401 |
| abstractText | Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the gamma-aminobutyric acidB (GABAB) receptor suppressed these seizures in lethargic mice, whereas agonists of GABAB receptors exacerbated them. Furthermore, GABAB receptor binding and synaptically evoked GABAB receptor-mediated inhibition of N-methyl-D-aspartate responses were selectively increased in lh/lh mice. Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures. |
