| First Author | Sviderskaya EV | Year | 1998 |
| Journal | Genetics | Volume | 148 |
| Issue | 1 | Pages | 381-90 |
| PubMed ID | 9475748 | Mgi Jnum | J:45425 |
| Mgi Id | MGI:1195414 | Doi | 10.1093/genetics/148.1.381 |
| Citation | Sviderskaya EV, et al. (1998) The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat. Genetics 148(1):381-90 |
| abstractText | Although the recessive murine mutation misty (m) is well known, its phenotype pe has never been reported beyond brief descriptions of a dilution of coat Color and white spotting of the belly and extremities, suggesting a developmental mutation. A report in abstract has also suggested effects on white fat and body weight. Here, we report effects of the homozygous misty mutation on an unusual combination of three cell types: melanocytes, platelets, and brown fat. Brown fat appeared to be completely absent fr-om all expected locations in neonatal m/m mice. A prolonged bleeding time was observed; platelet count and platelet serotonin and ATP levels were normal, but the level of ADP in m/m platelets was low Primary cultures and immortal lines of melanocytes from m/m mice showed several abnormalities. There was a marked deficiency in net proliferation, suggesting that the color dilution and spotting in vivo may result from reduced numbers of melanocytes and their precursors. M/m melanocytes were also hyperdendritic in morphology, over- produced melanin, and had deficient responses to the cAMP agonists cholera toxin and melanocyte-stimulating hormone, which normally promote melanin production. The misty gene product map be involved in adenine nucleotide metabolism or signaling. |
