| First Author | Truett GE | Year | 1998 |
| Journal | Am J Physiol | Volume | 275 |
| Issue | 1 Pt 2 | Pages | R29-32 |
| PubMed ID | 9688956 | Mgi Jnum | J:48831 |
| Mgi Id | MGI:1275864 | Doi | 10.1152/ajpregu.1998.275.1.R29 |
| Citation | Truett GE, et al. (1998) Misty (m) affects growth traits. Am J Physiol 275(1 Pt 2):R29-32 |
| abstractText | The misty (m) coat color mutation is commonly maintained in linkage disequilibrium with the obesity mutation diabetes (Leprdb) to serve as a marker for Leprdb genotype. Comparisons among Leprdb genotypes are made under the untested assumption that m has no effects on traits under investigation. We tested this assumption in a population segregating m in the absence of db. Analysis of growth curves revealed that m/m mice are smaller than M/M mice by the 2nd wk of life and remain smaller through the 5th wk of life. Analysis of variance of three traits measured at 35 days of age revealed that m/m mice are 8% shorter than M/M mice, weigh 15% less, and have 21% less inguinal adipose mass. These results indicate that m affects growth traits. Therefore, when m and Leprdb segregate in the same cross, interpretation of their effects is confounded by linkage. More accurate estimates of Leprdb genotype effects can be made by removing m from populations segregating Leprdb and using a direct assay to measure Leprdb genotype. |
