| First Author | Messer A | Year | 1986 |
| Journal | J Neurogenet | Volume | 3 |
| Issue | 6 | Pages | 345-55 |
| PubMed ID | 3783318 | Mgi Jnum | J:8492 |
| Mgi Id | MGI:56958 | Doi | 10.3109/01677068609106858 |
| Citation | Messer A, et al. (1986) Autosomal dominance in a late-onset motor neuron disease in the mouse. J Neurogenet 3(6):345-55 |
| abstractText | A late-onset neurological disease has been identified in a substrain of C57Bl/6 mice. The disorder is characterized by hindlimb weakness and ataxia starting at 5-11 months of age, progressing to severe spastic paralysis of all limbs, with premature death. Histopathology reveals degeneration of upper and lower motoneurons. Both sexes are affected; the mice are fertile, although breeding efficiency is reduced. In outcrosses to wild-type, symptoms have been observed in all obligate heterozygotes, with a similar age range for onset to that of homozygotes. We have designated this autosomal dominant disorder Motor neuron degeneration (Mnd). |
