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Allele : Htra2<mnd2> HtrA serine peptidase 2; motor neuron degeneration 2

Primary Identifier  MGI:1856960 Allele Type  Spontaneous
Gene  Htra2 Inheritance Mode  Recessive
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  The mutation in the mnd2 mouse has been identified as an A-to-T transversion that causes a Ser276Cys change in the protease domain of the protein. This mutation has no effect on mRNA or protein concentrations. However, enzyme assays reveal that the serine protease activity of this protein is lost.
  • mutations:
  • Single point mutation
  • synonyms:
  • mnd2,
  • mnd2
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

7 Carried By

Trail: Allele

0 Driven By

21 Publication categories

Trail: Allele