| First Author | Woo D | Year | 2001 |
| Journal | Mol Cell Endocrinol | Volume | 176 |
| Issue | 1-2 | Pages | 155-62 |
| PubMed ID | 11369455 | Mgi Jnum | J:82596 |
| Mgi Id | MGI:2653768 | Doi | 10.1016/s0303-7207(00)00398-1 |
| Citation | Woo D, et al. (2001) Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism. Mol Cell Endocrinol 176(1-2):155-62 |
| abstractText | Ke 6 is a 17beta-hydroxysteroid dehydrogenase (17betaHSD) that is expressed in the kidneys and gonads. The expression of this gene is markedly reduced in three murine models of recessive polycystic kidney disease, a developmental disorder, where some nephrons within the affected kidneys develop into huge fluid-filled cysts while the non-cystic nephrons atrophies by apoptosis. Here, we show that in the cpk/cpk mouse, which have polycystic kidneys, the female reproductive organs also fail to mature properly and remain arrested at an early stage of development. Direct measurement of 17betaHSD activity showed a severe reduction in estrogen and androgen metabolism within gonadal and non-gonadal tissues of the cpk/cpk mouse. Using immunofluorescent staining we localized the expression of the Ke 6 protein within the female mouse reproductive organs. Our findings suggest that estrogen/androgen metabolism may play an important role in the development of the urogenital systems. |
