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Publication : Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4.

First Author  Beier DR Year  1995
Journal  Mamm Genome Volume  6
Issue  4 Pages  269-72
PubMed ID  7613032 Mgi Jnum  J:24376
Mgi Id  MGI:72142 Doi  10.1007/BF00352414
Citation  Beier DR, et al. (1995) Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4. Mamm Genome 6(4):269-72
abstractText  We have determined the order of a number of SSR and SSC polymorphic markers that map to distal mouse Chromosome (Chr) 4 and have used analysis of these markers in backcrosses designed to test the localization of the curly-tail (ct) mutation. We have confirmed that ct maps to this region, close to the locus D4Mit69. Our results also support the hypothesis that ct is a semidominant, rather than a recessive, mutation, since we have identified abnormal-tailed mice that are likely to be heterozygous at the ct locus. Finally, we examined Pax7 as a candidate gene for the ct mutation and found no evidence of protein sequence differences in ct compared with wild-type mice.
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