First Author | Beier DR | Year | 1995 |
Journal | Mamm Genome | Volume | 6 |
Issue | 4 | Pages | 269-72 |
PubMed ID | 7613032 | Mgi Jnum | J:24376 |
Mgi Id | MGI:72142 | Doi | 10.1007/BF00352414 |
Citation | Beier DR, et al. (1995) Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4. Mamm Genome 6(4):269-72 |
abstractText | We have determined the order of a number of SSR and SSC polymorphic markers that map to distal mouse Chromosome (Chr) 4 and have used analysis of these markers in backcrosses designed to test the localization of the curly-tail (ct) mutation. We have confirmed that ct maps to this region, close to the locus D4Mit69. Our results also support the hypothesis that ct is a semidominant, rather than a recessive, mutation, since we have identified abnormal-tailed mice that are likely to be heterozygous at the ct locus. Finally, we examined Pax7 as a candidate gene for the ct mutation and found no evidence of protein sequence differences in ct compared with wild-type mice. |