| First Author | Romero MI | Year | 1997 |
| Journal | Neuroendocrinology | Volume | 65 |
| Issue | 2 | Pages | 107-16 |
| PubMed ID | 9067988 | Mgi Jnum | J:38548 |
| Mgi Id | MGI:85929 | Doi | 10.1159/000127170 |
| Citation | Romero MI, et al. (1997) Identification of growth hormone-releasing hormone and somatostatin neurons projecting to the median eminence in normal and growth hormone-deficient Ames dwarf mice. Neuroendocrinology 65(2):107-16 |
| abstractText | In the spontaneous mutant Ames dwarf mouse, GH deficiency coincides with a dramatic increase in the expression of both mRNA and peptide for stimulatory GHRH and reduced expression of GH-inhibitory somatostatin (SRIH) mRNA and peptide. However, both GHRH and SRIH are markedly reduced in the dwarf median eminence (ME), suggesting that ME innervation by GHRH and SRIH neurons may be aberrant in the absence of GH. In order to test this hypothesis, the number of GHRH and SRIH ME-projecting neurons was evaluated in normal and dwarf mice using a combination of |
