| First Author | Schneider A | Year | 2017 |
| Journal | Mol Cell Endocrinol | Volume | 439 |
| Pages | 328-336 | PubMed ID | 27663076 |
| Mgi Jnum | J:252826 | Mgi Id | MGI:6095358 |
| Doi | 10.1016/j.mce.2016.09.019 | Citation | Schneider A, et al. (2017) Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice. Mol Cell Endocrinol 439:328-336 |
| abstractText | The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses. |
