| First Author | Zwaan J | Year | 1983 |
| Journal | Exp Eye Res | Volume | 36 |
| Issue | 4 | Pages | 551-7 |
| PubMed ID | 6343105 | Mgi Jnum | J:27145 |
| Mgi Id | MGI:74563 | Doi | 10.1016/0014-4835(83)90049-0 |
| Citation | Zwaan J, et al. (1983) Crystallin synthesis in the lens rudiment of a strain of mice with congenital anophthalmia. Exp Eye Res 36(4):551-7 |
| abstractText | Immunofluorescence with anti-crystallin antisera was done on the eye rudiments of mouse embryos of a congenitally anophthalmic strain. In a few of the embryos a lens vesicle formed, which, although much smaller than in controls and delayed in development, appeared morphologically normal. alpha-Crystallin could be identified in the cells of the rudiments. In addition the cells looked cytologically similar to those of the normal lens vesicle; they were elongated and the nuclei displayed interkinetic nuclear migration. Therefore, the surface ectoderm of the anophthalmia mouse can differentiate into a lens vesicle that appears biochemically and cytologically normal. This indicates that the optic vesicle in this mutant is capable of inducing a lens, while the surface ectoderm can respond to the stimulus in a normal fashion. |
