| First Author | Lenox LE | Year | 2005 |
| Journal | Blood | Volume | 105 |
| Issue | 7 | Pages | 2741-8 |
| PubMed ID | 15591122 | Mgi Jnum | J:98445 |
| Mgi Id | MGI:3578483 | Doi | 10.1182/blood-2004-02-0703 |
| Citation | Lenox LE, et al. (2005) BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood 105(7):2741-8 |
| abstractText | Acute anemia initiates a systemic response that results in the rapid mobilization and differentiation of erythroid progenitors in the adult spleen. The flexed-tail (f) mutant mice exhibit normal steady-state erythropoiesis but are unable to rapidly respond to acute erythropoietic stress. Here, we show that f/f mutant mice have a mutation in Madh5. Our analysis shows that BMP4/Madh5-dependent signaling, regulated by hypoxia, initiates the differentiation and expansion of erythroid progenitors in the spleen. These findings suggest a new model where stress erythroid progenitors, resident in the spleen, are poised to respond to changes in the microenvironment induced by acute anemia. |
