| First Author | Stubbs L | Year | 1990 |
| Journal | Genomics | Volume | 6 |
| Issue | 4 | Pages | 645-50 |
| PubMed ID | 1971250 | Mgi Jnum | J:10508 |
| Mgi Id | MGI:58958 | Doi | 10.1016/0888-7543(90)90499-k |
| Citation | Stubbs L, et al. (1990) The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics 6(4):645-50 |
| abstractText | Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved housekeeping genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2. |
