| First Author | McGarry MP | Year | 1999 |
| Journal | Exp Mol Pathol | Volume | 66 |
| Issue | 3 | Pages | 191-200 |
| PubMed ID | 10486237 | Mgi Jnum | J:106334 |
| Mgi Id | MGI:3618047 | Doi | 10.1006/exmp.1999.2270 |
| Citation | McGarry MP, et al. (1999) Increased incidence and analysis of emperipolesis in megakaryocytes of the mouse mutant gunmetal. Exp Mol Pathol 66(3):191-200 |
| abstractText | Mutant gunmetal (gm/gm) mice exhibit prolonged bleeding, platelet granule defects, abnormal megakaryocyte demarcation membranes, and thrombocytopenia. The number of megakaryocytes in gm/gm mice is increased substantially. Also, the percentage of gm/gm megakaryocytes exhibiting emperipolesis is increased. However, the number of emperipolesed cells per megakaryocyte is not. EC are of several hematopoietic lineages, with a slight skew to granulocytes, and include mature, primitive, and degenerating cells. No significant differences in the types of emperipolesed cells were observed between mutant mice and their normal gm/+ or +/+ counterparts. The increased incidence of emperipolesis in gm/gm megakaryocytes is controlled by the megakaryocyte genotype, not systemic factors. A significant practical finding of these studies was the demonstration that increased emperipolesis results in a significant 'right shift' in megakaryocyte ploidy determined by flow cytometry. |
