| First Author | Hibasami H | Year | 1994 |
| Journal | Biochim Biophys Acta | Volume | 1226 |
| Issue | 1 | Pages | 110-4 |
| PubMed ID | 8155732 | Mgi Jnum | J:18262 |
| Mgi Id | MGI:66268 | Doi | 10.1016/0925-4439(94)90066-3 |
| Citation | Hibasami H, et al. (1994) Expression of high activity of ornithine decarboxylase and occurrence of unusual chromophobic cells in anterior pituitary gland of a novel growth-retarded strain of mice, grm/grm. Biochim Biophys Acta 1226(1):110-4 |
| abstractText | Extremely high activity of ornithine decarboxylase (ODC) was detected in the pituitary gland of growth-retarded mice, grm/grm at 2 months after birth. The elevated enzyme activity gradually decreased to the control level in 14 months after birth. In the pituitary gland of the growth-retarded mice, unusual chromophobic cells were also present from the early stages after birth. The chromophobic cells showed conspicuous proliferations and resulted in a distinct hyperplasia of the tissue after 4 months after birth. These findings suggest that ODC is correlated to the progressive transformation of pituitary cells into the chromophobic cells. |
