| First Author | Brand MP | Year | 1996 |
| Journal | Brain Res | Volume | 735 |
| Issue | 1 | Pages | 169-72 |
| PubMed ID | 8905183 | Mgi Jnum | J:35898 |
| Mgi Id | MGI:83341 | Doi | 10.1016/0006-8993(96)00892-x |
| Citation | Brand MP, et al. (1996) Impairment of the nitric oxide/cyclic GMP pathway in cerebellar slices prepared from the hph-1 mouse. Brain Res 735(1):169-72 |
| abstractText | In this study, the effect of tetrahydrobiopterin deficiency on the nitric oxide/cGMP pathway has been investigated in cerebellar slices derived from the hph-1 mouse. This animal displays a partial deficiency of tetrahydrobiopterin. Basal levels of cGMP were significantly reduced (-29.5%) in the hph-1 mouse cerebellum compared to controls. Following kainate stimulation (500 mu M) cGMP levels increased in both control and hph-1 preparations but were again significantly lower (-29.1%) in the hph-1 mouse. Exposure of slices to the nitric oxide donors, S-nitroso-N- acetylpenicillamine and S-nitroso-glutathione, revealed no difference in cGMP accumulation between the two groups. These findings suggest that the cerebellar nitric oxide/ cGMP pathway may be impaired in partial tetrahydrobiopterin deficiency states due to diminished nitric oxide formation. |
