| First Author | Ruppert S | Year | 1990 |
| Journal | Cell | Volume | 61 |
| Issue | 5 | Pages | 895-904 |
| PubMed ID | 2344618 | Mgi Jnum | J:10522 |
| Mgi Id | MGI:58972 | Doi | 10.1016/0092-8674(90)90200-x |
| Citation | Ruppert S, et al. (1990) Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell 61(5):895-904 |
| abstractText | Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive transacting factor, denoted alf, in deletion homozygotes. Using differential cDNA screening, we isolated and characterized genes whose cell type-specific transcription is affected by alf and found as a common feature that expression of these genes is induced by glucocorticoids and cAMP. Surprisingly, a subset of these alf-responsive genes is negatively controlled by the tissue-specific extinguisher locus Tse-1. Administration of glucocorticoids and cAMP leads to reversal of Tse-1-mediated extinction of these genes. These results show that two trans-acting factors coordinately regulate expression of overlapping sets of liver-specific genes. We suggest that both the lethal phenotype and the extinguished state result from interference with hormone signal transduction. |
