| First Author | Ikeya M | Year | 2001 |
| Journal | Mech Dev | Volume | 103 |
| Issue | 1-2 | Pages | 27-33 |
| PubMed ID | 11335109 | Mgi Jnum | J:69781 |
| Mgi Id | MGI:2135432 | Doi | 10.1016/s0925-4773(01)00338-0 |
| Citation | Ikeya M, et al. (2001) Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev 103(1-2):27-33 |
| abstractText | In vertebrates, each vertebra along the anteroposterior axis has a characteristic structure. It has recently been shown that several transcription factors and cell signaling molecules expressed in the primitive streak ectoderm and/or the tailbud play essential roles in establishing the correct anteroposterior specification of vertebrae during mouse development. Here, we report that Wnt-3a mutants exhibit homeotic transformations in the vertebrae along their entire body axis. In addition, reduced expression of cdx-1, the mutation of which results in an anterior transformation, as occurs in Wnt-3a mutants, was observed in the primitive streak and tail bud region of Wnt-3a mutant embryos. These results indicate that Wnt-3a is necessary for correct anteroposterior patterning of vertebra, and that cdx-1 may be one of the mediator genes of Wnt-3a signaling in this process. |
