| First Author | Mombaerts P | Year | 1992 |
| Journal | Nature | Volume | 360 |
| Issue | 6401 | Pages | 225-31 |
| PubMed ID | 1359428 | Mgi Jnum | J:3206 |
| Mgi Id | MGI:51721 | Doi | 10.1038/360225a0 |
| Citation | Mombaerts P, et al. (1992) Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491]. Nature 360(6401):225-31 |
| abstractText | Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta. |
