| First Author | Sun G | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 4 | Pages | 373-81 |
| PubMed ID | 15750595 | Mgi Jnum | J:97610 |
| Mgi Id | MGI:3575940 | Doi | 10.1038/ni1183 |
| Citation | Sun G, et al. (2005) The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol 6(4):373-81 |
| abstractText | The genetic programs directing CD4 or CD8 T cell differentiation in the thymus remain poorly understood. While analyzing gene expression during intrathymic T cell selection, we found that Zfp67, encoding the zinc finger transcription factor cKrox, was upregulated during the differentiation of CD4(+) but not CD8(+) T cells. Expression of a cKrox transgene impaired CD8 T cell development and caused major histocompatibility complex class I-restricted thymocytes to differentiate into CD4(+) T cells with helper properties rather than into cytotoxic CD8(+) T cells, as normally found. CD4 lineage differentiation mediated by cKrox required its N-terminal BTB (bric-a-brac, tramtrack, broad complex) domain. These findings identify cKrox as a chief CD4 differentiation factor during positive selection. |
