| First Author | Mizoguchi A | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 2 | Pages | 219-30 |
| PubMed ID | 11869683 | Mgi Jnum | J:74718 |
| Mgi Id | MGI:2159025 | Doi | 10.1016/s1074-7613(02)00274-1 |
| Citation | Mizoguchi A, et al. (2002) Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation. Immunity 16(2):219-30 |
| abstractText | B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions. |
