| First Author | Toney LM | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 3 | Pages | 214-20 |
| PubMed ID | 10973278 | Mgi Jnum | J:118449 |
| Mgi Id | MGI:3699587 | Doi | 10.1038/79749 |
| Citation | Toney LM, et al. (2000) BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol 1(3):214-20 |
| abstractText | The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity. |
