| First Author | Kim C | Year | 2013 |
| Journal | Immunity | Volume | 39 |
| Issue | 3 | Pages | 508-20 |
| PubMed ID | 24054329 | Mgi Jnum | J:208206 |
| Mgi Id | MGI:5562482 | Doi | 10.1016/j.immuni.2013.08.033 |
| Citation | Kim C, et al. (2013) Sustained interactions between T cell receptors and antigens promote the differentiation of CD4(+) memory T cells. Immunity 39(3):508-20 |
| abstractText | During CD4(+) T cell activation, T cell receptor (TCR) signals impact T cell fate, including recruitment, expansion, differentiation, trafficking, and survival. To determine the impact of TCR signals on the fate decision of activated CD4(+) T cells to become end-stage effector or long-lived memory T helper 1 (Th1) cells, we devised a deep-sequencing-based approach that allowed us to track the evolution of TCR repertoires after acute infection. The transition of effector Th1 cells into the memory pool was associated with a significant decrease in repertoire diversity, and the major histocompatibility complex (MHC) class II tetramer off rate, but not tetramer avidity, was a key predictive factor in the representation of individual clonal T cell populations at the memory stage. We conclude that stable and sustained interactions with antigens during the development of Th1 responses to acute infection are a determinative factor in promoting the differentiation of Th1 memory cells. |
