| First Author | Henrickson SE | Year | 2013 |
| Journal | Immunity | Volume | 39 |
| Issue | 3 | Pages | 496-507 |
| PubMed ID | 24054328 | Mgi Jnum | J:208207 |
| Mgi Id | MGI:5562483 | Doi | 10.1016/j.immuni.2013.08.034 |
| Citation | Henrickson SE, et al. (2013) Antigen availability determines CD8(+) T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity 39(3):496-507 |
| abstractText | T cells are activated by antigen (Ag)-bearing dendritic cells (DCs) in lymph nodes in three phases. The duration of the initial phase of transient, serial DC-T cell interactions is inversely correlated with Ag dose. The second phase, characterized by stable DC-T cell contacts, is believed to be necessary for full-fledged T cell activation. Here we have shown that this is not the case. CD8(+) T cells interacting with DCs presenting low-dose, short-lived Ag did not transition to phase 2, whereas higher Ag dose yielded phase 2 transition. Both antigenic constellations promoted T cell proliferation and effector differentiation but yielded different transcriptome signatures at 12 hr and 24 hr. T cells that experienced phase 2 developed long-lived memory, whereas conditions without stable contacts yielded immunological amnesia. Thus, T cells make fate decisions within hours after Ag exposure, resulting in long-term memory or abortive effector responses, correlating with T cell-DCs interaction kinetics. |
