| First Author | Hou B | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 3 | Pages | 375-84 |
| PubMed ID | 21353603 | Mgi Jnum | J:170704 |
| Mgi Id | MGI:4947166 | Doi | 10.1016/j.immuni.2011.01.011 |
| Citation | Hou B, et al. (2011) Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response. Immunity 34(3):375-84 |
| abstractText | The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses. |
