| First Author | Meli AP | Year | 2016 |
| Journal | Immunity | Volume | 45 |
| Issue | 4 | Pages | 831-846 |
| PubMed ID | 27760339 | Mgi Jnum | J:259939 |
| Mgi Id | MGI:6141640 | Doi | 10.1016/j.immuni.2016.09.018 |
| Citation | Meli AP, et al. (2016) The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance. Immunity 45(4):831-846 |
| abstractText | T follicular helper (Tfh) cells are a CD4(+) T cell subset critical for long-lived humoral immunity. We hypothesized that integrins play a decisive role in Tfh cell biology. Here we show that Tfh cells expressed a highly active form of leukocyte function-associated antigen-1 (LFA-1) that was required for their survival within the germinal center niche. In addition, LFA-1 promoted expression of Bcl-6, a transcriptional repressor critical for Tfh cell differentiation, and inhibition of LFA-1 abolished Tfh cell generation and prevented protective humoral immunity to intestinal helminth infection. Furthermore, we demonstrated that expression of Talin-1, an adaptor protein that regulates LFA-1 affinity, dictated Tfh versus Th2 effector cell differentiation. Collectively, our results define unique functions for LFA-1 in the Tfh cell effector program and suggest that integrin activity is important in lineage decision-making events in the adaptive immune system. |
