| First Author | Hao J | Year | 2011 |
| Journal | J Immunol | Volume | 187 |
| Issue | 10 | Pages | 4979-86 |
| PubMed ID | 21987661 | Mgi Jnum | J:179639 |
| Mgi Id | MGI:5302787 | Doi | 10.4049/jimmunol.1101389 |
| Citation | Hao J, et al. (2011) Regulatory role of Vgamma1 gammadelta T cells in tumor immunity through IL-4 production. J Immunol 187(10):4979-86 |
| abstractText | It has been demonstrated that the two main subsets of peripheral gammadelta T cells, Vgamma1 and Vgamma4, have divergent functions in many diseases models. Recently, we reported that Vgamma4 gammadelta T cells played a protective role in tumor immunity through eomesodermin-controlled mechanisms. However, the precise roles of Vgamma1 gammadelta T cells in tumor immunity, especially whether Vgamma1 gammadelta T cells have any interaction with Vgamma4 gammadelta T cells, remain unknown. We demonstrated in this paper that Vgamma1 gammadelta T cells suppressed Vgamma4 gammadelta T cell-mediated antitumor function both in vitro and in vivo, and this suppression was cell contact independent. Using neutralizing anti-IL-4 Ab or IL-4(-/-) mice, we determined the suppressive factor derived from Vgamma1 gammadelta T cells was IL-4. Indeed, treatment of Vgamma4 gammadelta T cells with rIL-4 significantly reduced expression levels of NKG2D, perforin, and IFN-gamma. Finally, Vgamma1 gammadelta T cells produced more IL-4 and expressed significantly higher level of GATA-3 upon Th2 priming in comparison with Vgamma4 gammadelta T cells. Therefore, to our knowledge, our results established for the first time a negative regulatory role of Vgamma1 gammadelta T cells in Vgamma4 gammadelta T cell-mediated antitumor immunity through cell contact-independent and IL-4-mediated mechanisms. Selective depletion of this suppressive subset of gammadelta T cells may be beneficial for tumor immune therapy. |
