| First Author | Zhou X | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 11 | Pages | 113452 |
| PubMed ID | 37976163 | Mgi Jnum | J:355301 |
| Mgi Id | MGI:7567257 | Doi | 10.1016/j.celrep.2023.113452 |
| Citation | Zhou X, et al. (2023) MHC class II regulation of CD8(+) T cell tolerance and implications in autoimmunity and cancer immunotherapy. Cell Rep 42(11):113452 |
| abstractText | Major histocompatibility complex (MHC) class II-reactive CD8(+) T cells are found in humans and animals, but little is known about their identity, development, and function. In this study, we discover a group of CD8(+) T cells reactive to both MHC class I and II molecules in MHC class II-deficient mice. We clone their T cell receptors (TCRs) and analyze their development and function. In wild-type animals, thymocytes bearing those TCRs are purged by negative selection. In the absence of MHC class II, they develop into mature CD8(+) T cells. When encountering MHC class II in the periphery, they undergo robust activation and proliferation, attack self-tissues, and cause lethal autoimmune diseases. In adoptive T cell therapy, those CD8(+) T cells are able to efficiently control MHC class II-expressing tumors. This study opens the door to investigation of dual-reactive CD8(+) T cells, their development and selection in the thymus, and the perils and promises when their normal development and selection are compromised. |
