| First Author | Tsuji M | Year | 2008 |
| Journal | Immunity | Volume | 29 |
| Issue | 2 | Pages | 261-71 |
| PubMed ID | 18656387 | Mgi Jnum | J:139002 |
| Mgi Id | MGI:3807097 | Doi | 10.1016/j.immuni.2008.05.014 |
| Citation | Tsuji M, et al. (2008) Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin a generation in the gut. Immunity 29(2):261-71 |
| abstractText | Immunoglobulin A (IgA) is generated in the gut by both T cell-dependent and T cell-independent processes. The sites and the mechanisms for T cell-independent IgA synthesis remain elusive. Here we show that isolated lymphoid follicles (ILFs) were sites where induction of activation-induced cytidine deaminase (AID) and IgA class switching of B cells took place in the absence of T cells. We also show that formation of ILFs was regulated by interactions between lymphoid tissue-inducer cells expressing the nuclear receptor RORgammat (RORgammat(+)LTi cells) and stromal cells (SCs). Activation of SCs by RORgammat(+)LTi cells through lymphotoxin (LT)-beta receptor (LTbetaR) and simultaneously by bacteria through TLRs induced recruitment of dendritic cells (DCs) and B cells and formation of ILFs. These findings provide insight into the crosstalk between bacteria, RORgammat(+)LTi cells, SCs, DCs, and B cells required for ILF formation and establish a critical role of ILFs in T cell-independent IgA synthesis in gut. |
