| First Author | Cunningham CA | Year | 2017 |
| Journal | J Immunol | Volume | 198 |
| Issue | 12 | Pages | 4575-4580 |
| PubMed ID | 28507025 | Mgi Jnum | J:252345 |
| Mgi Id | MGI:5927091 | Doi | 10.4049/jimmunol.1700465 |
| Citation | Cunningham CA, et al. (2017) Cutting Edge: Defective Aerobic Glycolysis Defines the Distinct Effector Function in Antigen-Activated CD8+ Recent Thymic Emigrants. J Immunol 198(12):4575-4580 |
| abstractText | Recent thymic emigrants (RTEs) are the youngest peripheral T cells that have completed thymic selection and egress to the lymphoid periphery. RTEs are functionally distinct from their more mature but still naive T cell counterparts, because they exhibit dampened proliferation and reduced cytokine production upon activation. In this article, we show that, compared with more mature but still naive T cells, RTEs are impaired in their ability to perform aerobic glycolysis following activation. Impaired metabolism underlies the reduced IFN-gamma production observed in activated RTEs. This failure to undergo Ag-induced aerobic glycolysis is caused by reduced mTORC1 activity and diminished Myc induction in RTEs. Critically, exogenous IL-2 restores Myc expression in RTEs, driving aerobic glycolysis and IFN-gamma production to the level of mature T cells. These results reveal a previously unknown metabolic component to postthymic T cell maturation. |
