| First Author | Botta D | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 11 | Pages | 1249-1260 |
| PubMed ID | 28892471 | Mgi Jnum | J:260605 |
| Mgi Id | MGI:6142566 | Doi | 10.1038/ni.3837 |
| Citation | Botta D, et al. (2017) Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection. Nat Immunol 18(11):1249-1260 |
| abstractText | Interleukin 2 (IL-2) promotes Foxp3(+) regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses. |
