| First Author | Grootjans J | Year | 2019 |
| Journal | Science | Volume | 363 |
| Issue | 6430 | Pages | 993-998 |
| PubMed ID | 30819965 | Mgi Jnum | J:273631 |
| Mgi Id | MGI:6294024 | Doi | 10.1126/science.aat7186 |
| Citation | Grootjans J, et al. (2019) Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science 363(6430):993-998 |
| abstractText | Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI and microbiota-independent expansion and activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA. Increased numbers of IgA-producing plasma cells were observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress. Upon ER stress, IECs communicate signals to the peritoneum that induce a barrier-protective TI IgA response. |
