| First Author | Gay D | Year | 2013 |
| Journal | Nat Med | Volume | 19 |
| Issue | 7 | Pages | 916-23 |
| PubMed ID | 23727932 | Mgi Jnum | J:199838 |
| Mgi Id | MGI:5505366 | Doi | 10.1038/nm.3181 |
| Citation | Gay D, et al. (2013) Fgf9 from dermal gammadelta T cells induces hair follicle neogenesis after wounding. Nat Med 19(7):916-23 |
| abstractText | Understanding molecular mechanisms for regeneration of hair follicles provides new opportunities for developing treatments for hair loss and other skin disorders. Here we show that fibroblast growth factor 9 (Fgf9), initially secreted by gammadelta T cells, modulates hair follicle regeneration after wounding the skin of adult mice. Reducing Fgf9 expression decreases this wound-induced hair neogenesis (WIHN). Conversely, overexpression of Fgf9 results in a two- to threefold increase in the number of neogenic hair follicles. We found that Fgf9 from gammadelta T cells triggers Wnt expression and subsequent Wnt activation in wound fibroblasts. Through a unique feedback mechanism, activated fibroblasts then express Fgf9, thus amplifying Wnt activity throughout the wound dermis during a crucial phase of skin regeneration. Notably, humans lack a robust population of resident dermal gammadelta T cells, potentially explaining their inability to regenerate hair after wounding. These findings highlight the essential relationship between the immune system and tissue regeneration. The importance of Fgf9 in hair follicle regeneration suggests that it could be used therapeutically in humans. |
