| First Author | Inoue S | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 13 | Pages | 2147-53 |
| PubMed ID | 24815981 | Mgi Jnum | J:211035 |
| Mgi Id | MGI:5573058 | Doi | 10.1016/j.febslet.2014.04.035 |
| Citation | Inoue S, et al. (2014) The protective effect of CD40 ligand-CD40 signalling is limited during the early phase of Plasmodium infection. FEBS Lett 588(13):2147-53 |
| abstractText | gammadelta T cells are essential for eliminating Plasmodium berghei XAT. Because administration of the agonistic anti-CD40 antibody can induce elimination of P. berghei XAT parasites in gammadelta T cell-deficient mice, we considered that gammadelta T cells might activate dendritic cells via CD40 signalling during infection. Here we report that administration of the anti-CD40 antibody to gammadelta T cell-deficient mice 3-10days post-P. berghei XAT infection could eliminate the parasites. Our data suggest that dendritic cell activation via gammadelta T cells expressing CD40 ligand is critical during the early phase of infection. |
