| First Author | Andrew EM | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 3 | Pages | 1741-50 |
| PubMed ID | 16034115 | Mgi Jnum | J:105477 |
| Mgi Id | MGI:3615256 | Doi | 10.4049/jimmunol.175.3.1741 |
| Citation | Andrew EM, et al. (2005) Delineation of the function of a major gamma delta T cell subset during infection. J Immunol 175(3):1741-50 |
| abstractText | Gammadelta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gammadelta T cells. Using mice deficient in Vgamma1+ T cells which are a major component of the gammadelta T cell response to microbial infection, a specific immunoregulatory role for Vgamma1+ T cells in macrophage and gammadelta T cell homeostasis during infection has been established. By contrast, Vgamma1+ T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited Vgamma1+ T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of Vgamma1+ T cells. These findings, therefore, identify distinct and nonoverlapping roles for gammadelta T cell subsets in infection and establish the complexity and adaptability of a single population of gammadelta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors. |
