| First Author | Wu X | Year | 2010 |
| Journal | Cell Stem Cell | Volume | 7 |
| Issue | 5 | Pages | 571-80 |
| PubMed ID | 21040899 | Mgi Jnum | J:167538 |
| Mgi Id | MGI:4868521 | Doi | 10.1016/j.stem.2010.09.012 |
| Citation | Wu X, et al. (2010) Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling. Cell Stem Cell 7(5):571-80 |
| abstractText | The anabolic effects of parathyroid hormone (PTH) on bone formation are impaired by concurrent use of antiresorptive drugs. We found that the release of active transforming growth factor (TGF)-beta1 during osteoclastic bone resorption is inhibited by alendronate. We showed that mouse Sca-1-positive (Sca-1(+)) bone marrow stromal cells are a skeletal stem cell subset, which are recruited to bone remodeling sites by active TGF-beta1 in response to bone resorption. Alendronate inhibits the release of active TGF-beta1 and the recruitment of Sca-1(+) skeletal stem cells for the bone formation. The observation was validated in a Tgfb1(-/-) mouse model, in which the anabolic effects of PTH on bone formation are diminished. The PTH-stimulated recruitment of injected mouse Sca-1(+) cells to the resorptive sites was inhibited by alendronate. Thus, inhibition of active TGF-beta1 release by alendronate reduces the recruitment of Sca-1(+) skeletal stem cells and impairs the anabolic action of PTH in bone. |
