| First Author | Do JS | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 4 | Pages | 1675-9 |
| PubMed ID | 20061408 | Mgi Jnum | J:159493 |
| Mgi Id | MGI:4443173 | Doi | 10.4049/jimmunol.0903539 |
| Citation | Do JS, et al. (2010) Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism. J Immunol 184(4):1675-9 |
| abstractText | In naive animals, gammadelta T cells are innate sources of IL-17, a potent proinflammatory cytokine mediating bacterial clearance as well as autoimmunity. However, mechanisms underlying the generation of these cells in vivo remain unclear. In this study, we show that TGF-beta1 plays a key role in the generation of IL-17(+) gammadelta T cells and that it mainly occurs in the thymus particularly during the postnatal period. Interestingly, IL-17(+) gammadelta TCR(+) thymocytes were mainly CD44(high)CD25(low) cells, which seem to derive from double-negative 4 gammadelta TCR(+) cells that acquired CD44 and IL-17 expression. Our findings identify a novel developmental pathway during which IL-17-competent gammadelta T cells arise in the thymus by a TGF-beta1-dependent mechanism. |
