| First Author | Letterio JJ | Year | 1998 |
| Journal | Miner Electrolyte Metab | Volume | 24 |
| Issue | 2-3 | Pages | 161-7 |
| PubMed ID | 9525700 | Mgi Jnum | J:46776 |
| Mgi Id | MGI:1202054 | Doi | 10.1159/000057365 |
| Citation | Letterio JJ, et al. (1998) TGF-beta knockout and dominant-negative receptor transgenic mice. Miner Electrolyte Metab 24(2-3):161-7 |
| abstractText | Use of homologous recombination and transgenic technologies have provided mouse models to study the physiological roles of the three mammalian TGF-beta isoforms, and their regulation in the context of the intact animal. Mice harboring null mutations for TGF-beta isoforms demonstrate that each exerts discrete nonoverlapping functions during development. TGF-beta1 null mice reveal a crucial role for this cytokine in modulation of the immune system, with evidence for altered development, activation and function of various immune cell populations. New approaches to tissue- and cell-restricted disruption of TGF-beta signaling pathways in transgenic mice carrying dominant-negative mutant TGF-beta receptors will be discussed. |
