| First Author | Barone KS | Year | 1998 |
| Journal | J Immunol | Volume | 161 |
| Issue | 1 | Pages | 154-60 |
| PubMed ID | 9647219 | Mgi Jnum | J:110924 |
| Mgi Id | MGI:3641528 | Doi | 10.4049/jimmunol.161.1.154 |
| Citation | Barone KS, et al. (1998) Induction of oral tolerance in TGF-beta 1 null mice. J Immunol 161(1):154-60 |
| abstractText | Previous studies have suggested that oral tolerance induction by low doses of Ag is mediated by inhibitory cytokines, particularly TGF-beta 1. To examine the roles of TGF-beta 1 and other inhibitory cytokines in the induction of oral tolerance, TGF-beta 1 null mice and controls were gavaged with 10 to 20 mg (high dose) or 1 mg (low dose) of OVA for 3 days. After immunization with OVA, the in vitro proliferative response of OVA-specific popliteal lymph node cells was assessed. Lymphocytes from all TGF-beta 1 null mice fed high doses of OVA exhibited highly significant suppression compared with controls. A weaker, but still significant, suppression was observed in lymphocytes from the majority of TGF-beta 1 null mice fed low doses of OVA. In addition, supernatants from these lymphocytes exhibited lower levels of IL-4, IL-10, and IFN-gamma than those from water-fed control animals. These results indicate that while TGF-beta 1 may play a role in suppression, inhibitory cytokines are not the exclusive mechanism by which low dose oral tolerance is induced. |
