| First Author | Palin K | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 187 |
| Issue | 1-2 | Pages | 55-60 |
| PubMed ID | 17512609 | Mgi Jnum | J:128857 |
| Mgi Id | MGI:3768196 | Doi | 10.1016/j.jneuroim.2007.04.011 |
| Citation | Palin K, et al. (2007) TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I. J Neuroimmunol 187(1-2):55-60 |
| abstractText | A variety of pathogenic insults cause synthesis of tumor necrosis factor (TNF)alpha in the brain, resulting in sickness behavior. Here we used TNF-receptor (TNF-R)2-deficient and wild-type mice to demonstrate that the reduction in social exploration of a novel juvenile, the increase in immobility and the loss of body weight caused by central TNFalpha (i.c.v., 50 ng/mouse) are blocked by central pre-treatment with the multifunctional peptide, insulin-like growth factor (IGF-I; i.c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain. |
