| First Author | Fumagalli A | Year | 2020 |
| Journal | Cell Stem Cell | Volume | 26 |
| Issue | 4 | Pages | 569-578.e7 |
| PubMed ID | 32169167 | Mgi Jnum | J:358567 |
| Mgi Id | MGI:6713496 | Doi | 10.1016/j.stem.2020.02.008 |
| Citation | Fumagalli A, et al. (2020) Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer. Cell Stem Cell 26(4):569-578.e7 |
| abstractText | Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenografts to investigate the cell of origin of metastases. We found that most disseminated CRC cells in circulation were Lgr5(-) and formed distant metastases in which Lgr5(+) CSCs appeared. This plasticity occurred independently of stemness-inducing microenvironmental factors and was indispensable for outgrowth, but not establishment, of metastases. Together, these findings show that most colorectal cancer metastases are seeded by Lgr5(-) cells, which display intrinsic capacity to become CSCs in a niche-independent manner and can restore epithelial hierarchies in metastatic tumors. |
