| First Author | Kawauchi D | Year | 2012 |
| Journal | Cancer Cell | Volume | 21 |
| Issue | 2 | Pages | 168-80 |
| PubMed ID | 22340591 | Mgi Jnum | J:181462 |
| Mgi Id | MGI:5311486 | Doi | 10.1016/j.ccr.2011.12.023 |
| Citation | Kawauchi D, et al. (2012) A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21(2):168-80 |
| abstractText | Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis. |
