| First Author | Chang CY | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 3371 |
| PubMed ID | 34099671 | Mgi Jnum | J:314453 |
| Mgi Id | MGI:6725370 | Doi | 10.1038/s41467-021-23587-x |
| Citation | Chang CY, et al. (2021) Tumor suppressor p53 regulates intestinal type 2 immunity. Nat Commun 12(1):3371 |
| abstractText | The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca(2+) influx and IL-25 release, which are critical triggers of type 2 innate lymphoid cell response. Our results thus reveal a previously unrecognized function of p53 in regulating intestinal type 2 immunity to protect against parasitic infections, highlighting the role of p53 as a guardian of immune integrity. |
