| First Author | Wang X | Year | 2006 |
| Journal | J Cell Biol | Volume | 172 |
| Issue | 1 | Pages | 115-25 |
| PubMed ID | 16380437 | Mgi Jnum | J:104404 |
| Mgi Id | MGI:3611945 | Doi | 10.1083/jcb.200507106 |
| Citation | Wang X, et al. (2006) p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol 172(1):115-25 |
| abstractText | p53 is a well known tumor suppressor. We show that p53 also regulates osteoblast differentiation, bone formation, and osteoblast-dependent osteoclast differentiation. Indeed, p53(-)(/)(-) mice display a high bone mass phenotype, and p53(-)(/)(-) osteoblasts show accelerated differentiation, secondary to an increase in expression of the osteoblast differentiation factor osterix, as a result. Reporter assays indicate that p53 represses osterix transcription by the minimal promoter in a DNA-binding-independent manner. In addition, p53(-)(/)(-) osteoblasts have an enhanced ability to favor osteoclast differentiation, in association with an increase in expression of macrophage-colony stimulating factor, which is under the control of osterix. Furthermore, inactivating p53 is sufficient to rescue the osteoblast differentiation defects observed in mice lacking c-Abl, a p53-interacting protein. Thus, these results identify p53 as a novel regulator of osteoblast differentiation, osteoblast-dependent osteoclastogenesis, and bone remodeling. |
