| First Author | Vives V | Year | 2006 |
| Journal | Genes Dev | Volume | 20 |
| Issue | 10 | Pages | 1262-7 |
| PubMed ID | 16702401 | Mgi Jnum | J:108701 |
| Mgi Id | MGI:3624572 | Doi | 10.1101/gad.374006 |
| Citation | Vives V, et al. (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20(10):1262-7 |
| abstractText | ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was accelerated by gamma-irradiation or in p53+/- background. Tumors derived from ASPP2+/- mice retained wild-type ASPP2 allele even though some of them lost p53. These provide the first genetic evidence that ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression. |
