| First Author | Lee CL | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 8477 | PubMed ID | 26399548 |
| Mgi Jnum | J:227224 | Mgi Id | MGI:5699937 |
| Doi | 10.1038/ncomms9477 | Citation | Lee CL, et al. (2015) Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. Nat Commun 6:8477 |
| abstractText | Genotoxic cancer therapies, such as chemoradiation, cause haematological toxicity primarily by activating the tumour suppressor p53. While inhibiting p53-mediated cell death during cancer therapy ameliorates haematologic toxicity, whether it also impacts carcinogenesis remains unclear. Here we utilize a mouse model of inducible p53 short hairpin RNA (shRNA) to show that temporarily blocking p53 during total-body irradiation (TBI) not only ameliorates acute toxicity, but also improves long-term survival by preventing lymphoma development. Using Kras(LA1) mice, we show that TBI promotes the expansion of a rare population of thymocytes that express oncogenic Kras(G12D). However, blocking p53 during TBI significantly suppresses the expansion of Kras(G12D)-expressing thymocytes. Mechanistically, bone marrow transplant experiments demonstrate that TBI activates p53 to decrease the ability of bone marrow cells to suppress lymphoma development through a non-cell-autonomous mechanism. Together, our results demonstrate that the p53 response to acute DNA damage promotes the development of radiation-induced lymphoma. |
