| First Author | de Stanchina E | Year | 1998 |
| Journal | Genes Dev | Volume | 12 |
| Issue | 15 | Pages | 2434-42 |
| PubMed ID | 9694807 | Mgi Jnum | J:115135 |
| Mgi Id | MGI:3690705 | Doi | 10.1101/gad.12.15.2434 |
| Citation | de Stanchina E, et al. (1998) E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 12(15):2434-42 |
| abstractText | The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor suppressor p19(ARF). The ability of E1A to induce p53 and its transcriptional targets is severely compromised in ARF-null cells, which remain resistant to apoptosis following serum depletion or adriamycin treatment. Reintroduction of p19(ARF) restores p53 accumulation and resensitizes ARF-null cells to apoptotic signals. Therefore, p19(ARF) functions as part of a p53-dependent failsafe mechanism to counter uncontrolled proliferation. Synergistic effects between the p19(ARF) and DNA damage pathways in inducing p53 may contribute to E1A's ability to enhance radio- and chemosensitivity. |
