| First Author | Terrinoni A | Year | 2011 |
| Journal | Oncogene | Volume | 30 |
| Issue | 27 | Pages | 3096-103 |
| PubMed ID | 21478910 | Mgi Jnum | J:174713 |
| Mgi Id | MGI:5140656 | Doi | 10.1038/onc.2011.31 |
| Citation | Terrinoni A, et al. (2011) OTX1 expression in breast cancer is regulated by p53. Oncogene 30(27):3096-103 |
| abstractText | The p53 transcription factor has a critical role in cell stress response and in tumor suppression. Wild-type p53 protein is a growth modulator and its inactivation is a critical event in malignant transformation. It has been recently demonstrated that wild-type p53 has developmental and differentiation functions. Indeed an over-expression of p53 in tumor cells induces asymmetrical division avoiding self-renewal of cancer stem cells (CSCs) and instead promoting their differentiation. In this study, 28 human breast carcinomas have been analyzed for expression of wild-type p53 and of a pool of non-clustered homeobox genes. We demonstrated that orthodenticle homolog 1 gene (OTX1) is transcribed in breast cancer. We established that the p53 protein directly induces OTX1 expression by acting on its promoter. OTX1 has been described as a critical molecule for axon refinement in the developing cerebral cortex of mice, and its activity in breast cancer suggests a synergistic function with p53 in CSC differentiation. Wild-type p53 may regulate cellular differentiation by an alternative pathway controlling OTX1 signaling only in breast cancer cells and not in physiological conditions. |
