| First Author | Ghazzaui N | Year | 2017 |
| Journal | Oncotarget | Volume | 8 |
| Issue | 4 | Pages | 7059-7067 |
| PubMed ID | 27729620 | Mgi Jnum | J:307905 |
| Mgi Id | MGI:6726716 | Doi | 10.18632/oncotarget.12535 |
| Citation | Ghazzaui N, et al. (2017) The IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesis. Oncotarget 8(4):7059-7067 |
| abstractText | Deregulation and mutations of c-myc have been reported in multiple mature B-cell malignancies such as Burkitt lymphoma, myeloma and plasma cell lymphoma. After translocation into the immunoglobulin heavy chain (IgH) locus, c-myc is constitutively expressed under the control of active IgH cis-regulatory enhancers. Those located in the IgH 3' regulatory region (3'RR) are master control elements of transcription. Over the past decade numerous convincing demonstrations of 3'RR's contribution to mature c-myc-induced lymphomagenesis have been made using transgenic models with various types of IgH-c-myc translocations and transgenes. This review highlights how IgH 3'RR physiological functions play a critical role in c-myc deregulation during lymphomagenesis. |
