| First Author | Carver EA | Year | 2002 |
| Journal | Anat Rec | Volume | 268 |
| Issue | 2 | Pages | 90-2 |
| PubMed ID | 12221714 | Mgi Jnum | J:79294 |
| Mgi Id | MGI:2387743 | Doi | 10.1002/ar.10124 |
| Citation | Carver EA, et al. (2002) Craniosynostosis in Twist heterozygous mice: A model for Saethre-Chotzen syndrome. Anat Rec 268(2):90-2 |
| abstractText | Saethre-Chotzen syndrome is a common autosomal dominant form of craniosynostosis, the premature fusion of the sutures of the calvarial bones of the skull. Most Saethre-Chotzen syndrome cases are caused by haploinsufficiency for the TWIST gene. Mice heterozygous for a null mutation of the Twist gene replicate certain features of Saethre-Chotzen syndrome, but have not been reported to exhibit craniosynostosis. We demonstrate that Twist heterozygous mice exhibit fusions of the coronal suture and other cranial suture abnormalities, indicating that Twist heterozygous mice constitute a better animal model for Saethre-Chotzen syndrome than was previously appreciated. Anat Rec 268:90-92, 2002. |
