| First Author | Gadjeva M | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 9 | Pages | 2509-17 |
| PubMed ID | 17705134 | Mgi Jnum | J:124335 |
| Mgi Id | MGI:3721344 | Doi | 10.1002/eji.200737186 |
| Citation | Gadjeva M, et al. (2007) NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol 37(9):2509-17 |
| abstractText | Mice which lack the p50 subunit of NF-kappaB and are heterozygous for the p65 subunit (3X mice), are exquisitely sensitive to LPS-induced shock. Here, we demonstrate that prior to becoming moribund, 3X mice challenged with LPS develop a profound enteropathy. The enteropathy is characterized by defects in intestinal barrier function, increased epithelial apoptosis, and deregulated intestinal cytokine gene expression. The defect that sensitizes 3X mice to LPS-induced enteropathy is located within the innate immune compartment, as LPS induced similar findings in 3X mice lacking lymphocytes (3X/RAG). TNF-alpha depletion ameliorated the ability of LPS to induce pathology and TNF-alpha was able to independently induce similar findings, suggesting that TNF-alpha plays a critical role in the development of LPS-induced pathology in these mice. These data highlight that NF-kappaB subunits have essential functions in regulating intestinal homeostasis during acute inflammation. |
